State Police say that around 11:15 a.m., troopers assigned to the Charlton barracks responded to a one car rollover accident on I-90 Westbound just before Exit 8.
Two medical helicopters were called in to transport two patients, and as a result, State Police had to close all of the westbound lanes to allow the helicopters to land.
Two people were flown to the hospital with serious and life-threatening injuries. A third person was taken by ambulance to Charlton Hospital.
By 1 p.m. the breakdown and right lanes had reopened.
State Police say that traffic was backed up all the way up to Exit 10 west.