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Trials Showing Promise for Possible Cancer Vaccine

BOSTON (WGGB) — Measles, mumps and even the flu. They’re just a few of the ailments that may come to mind when you think about vaccines, but now a new therapeutic vaccine 15 years in the making could make cancer kill itself.

Cancer flies under the immune system’s radar, in many cases, remaining hidden until it’s too late.

Now, a personalized vaccine developed in-part by Doctor David Avigan is helping fight the potential killer.

“The goal of the vaccine is to see whether one can really re-educate our immune system to see cancer cells as foreign,” says Avigan.

Still in the early stages of development, the vaccine fuses a patient’s tumor cells with immune-stimulating dendritic cells.

The new cells are then injected back into patients.

Avigan adds, “What we saw was that there we very strong immune responses that were generated in these patients, against their own tumor cells.”

In a phase one trial of the vaccine, 66 percent of patients with advanced multiple myeloma stabilized for a period of time.

In other studies, Doctor Avigan says some patients saw their disease regress. He also hopes to use the vaccine as a way to prevent recurrence.

Howard Bleich found out he had acute leukemia two years ago. After four rounds of chemo, he was given the vaccine and “the last time they checked me, I had not relapsed.”

Howard’s wife wasn’t sure he’d live to see their 25th wedding anniversary. They’ve just celebrated their 26th.

The vaccine could one day prove to be an effective cancer treatment that spares patients from the harsh side effects of chemotherapy.

Phase two trials combining the vaccine with other medications are underway for acute leukemia, multiple myeloma, kidney cancer and breast cancer.

All the trials are currently enrolling.

If you are interested in possibly taking part, you can contact Beth Israel Deaconess Medical Center in Boston at (617) 667-9920.


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