State Police teamed up with the Springfield Police Department and various federal agencies, including the FBI, to plan and execute the raid.
It started early Friday morning and ended late Friday night.
During the raid, police seized two illegal handguns, shotgun shells, $7,500 worth of heroin, and over $1,000 in cash.
The suspects range in age from 15 to 55. Several arraignments are scheduled for Monday.
Most of the arrests were made in the northern section of Springfield.