Emergency personnel were notified of the accident on Route 10 at 5:52 p.m. today.
According to the Easthampton Police Department a 2007 Chevy pulled out in front of the motorcycle which caused the pair to crash.
45-year-old, William Champagne and 45-year-0ld, Carrieann Champagne were both transported to Baystate Medical Center in Springfield.
Police report Carrieann is in more serious condition than William.
The driver of the Chevy, 19-year-old, Sarah Boyle has been issued a citation for failure to use care in turning.