Wilson shook off a rough first half, which included a fumble on the opening possession, to record 215 yards passing and the go-ahead score. Running back Marshawn Lynch tallied 109 yards rushing on 22 carries including a 40-yard touchdown scamper in the third quarter.
The 49ers opened in strong fashion forcing the usually composed Wilson out of his element early. Already leading 3-0, quarterback Colin Kaepernick’s 58-yard run set up an Anthony Dixon one-yard touchdown score to put the visitors up 10-0.
Trailing 10-3 entering the 3rd, Lynch brought the Seahawks back into the game with the touchdown scamper, knotting things up at 10-10.
The ensuing possession, Kaepernick connected with receiver Anquan Boldin 26-yard touchdown pass to give San Francisco a 17-10 lead once again.
After a 40-yard Steven Hauschka field cut the deficit to 17-13, Wilson opened the fourth quarter by finding Kearse to give Seattle the lead for good.
After exchanging turnovers, Kaepernick lead one final drive reaching the Seahawks 18-yard line but threw an interception after linebacker pulled down the pass deflected by cornerback Richard Sherman intended for Michael Crabtree with 22 seconds remaining.